Allogeneic Peripheral Blood Stem Cell Transplantation as an Alternative to Allogeneic Bone Marrow Transplantation

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Allogeneic peripheral blood stem cell transplantation as an alternative to allogeneic bone marrow transplantation.

BMT, including 1) rapid hematopoietic engraftment, 2) less requirement for blood transfusion, antibiotic therapy and hospitalization days, and 3) avoidance of.risks and discomfort associated with general anesthesia for collecting hematopoietic stem cells (2). Taking these advantages into consideration, the use of PBSCwas applied for syngeneic and allogeneic transplantation in the early 1990' s....

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Allogeneic Bone Marrow Transplantation

A 1 3-yr-old male with acute myelogenous therapy. Then, 53 yr later, he developed leukemia was treated with various chemoan extramedullary relapse with a chlotherapy regimens for 3 yr and then underroma of his maxillary sinus. This case ilwent an allogeneic bone marrow translustrates the need for prolonged followup plantation. The donor marrow was sucof transplant recipients and suggests that c...

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Decision analysis of peripheral blood versus bone marrow hematopoietic stem cells for allogeneic hematopoietic cell transplantation.

Peripheral blood stem cells (PBSCs) and bone marrow (BM) hematopoietic stem cells represent therapeutic alternatives in allogeneic hematopoietic cell transplantation. Randomized controlled trials and an individual patient data meta-analysis (IPDMA) have demonstrated a decreased risk of disease relapse and an increased risk of acute and chronic graft-versus-host disease (aGVHD, cGVHD) in patient...

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Cytomegalovirus antigenemia is observed more frequently following allogeneic peripheral blood stem cell transplantation compared to bone marrow transplantation.

One of the major complications following hematopoietic stem cell transplantation (HSCT) is cytomegalovirus (CMV) infection. In our institution, three methods have been applied routinely for the diagnosis of CMV antigenemia (CMV-Ag): 1. Direct immunofluorescence microscopic (IFM) examination; 2. Flow cytometric (FC) analysis; and 3. Serological investigation. We were able to detect CMV-Ag by FC ...

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Cell-depleted Allogeneic Bone Marrow Transplantation

One of the major obstacles in allogeneic bone marrow transplantation (allo-BMT) is prolonged T cell dysfunction resulting in a variety of infectious complications in the months to years after hematologic engraftment. We previously showed that immobilized extracellular matrix (ECM) proteins such as fibronectin (FN), the CS-1 domain of FN, or collagen (CO) acted synergistically with immobilized a...

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ژورنال

عنوان ژورنال: Internal Medicine

سال: 1998

ISSN: 0918-2918,1349-7235

DOI: 10.2169/internalmedicine.37.1001